Abstract and Figures

• • October 2023
  DOI: 10.21203/rs.3.rs-3452783/v1
  • License CC BY 4.0

Lisdexamphetamine (LDX) is one of the drugs commonly used to treat attention deficit hyperactivity disorder (ADHD). However, its neurological side effects, particularly on cognition, are not fully understood. The present study focused on memory in rats treated with LDX. We compared them with controls in terms of behavioral responses and electrophysiological and histological properties in the hippocampus. Almost all behavioral results showed the destructive properties of LDX. Although LDX did not alter population spike (PS) amplitude, it increased the field excitatory postsynaptic potential (fEPSP) slope of evoked potentials of LTP components. The number of microglia and astrocytes increased significantly in the LDX group. Sholl analysis showed increased soma size and total process length in hippocampal astrocytes and microglia. Taken together, LDX may disrupt memory-related variables. However, more research is needed to clarify this.

Authors

• • Dr. Dr. Mojtaba Sani
  • Dr. Abbas Aliaghaei

Source Citation

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